Table 3 Relationship between α-synucleinopathy (AS) and a diagnosis of Parkinson’s disease (PD), visual hallucinations (VH) and auditory hallucinations (AH)
From: Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly
Brain area | % (brains showing AS) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
No PD (n = 201) | PD (n = 7) | OR (95% CI) | P | No VH (n = 196) | VH (n = 12) | OR (95% CI) | P | No AH (n = 194) | AH (n = 14) | OR (95% CI) | P | |
Substantia nigra | 11 | 50 | 7.8 (1.0 to 60.6) | <0.01 | 12 | 30 | 3.2 (0.5 to 15.5) | 0.09 | 11 | 31 | 3.5 (0.7 to 13.9) | 0.04 |
Vagus nucleus | 21 | 43 | 2.9 (0.4 to 17.8) | >0.2 | 21 | 25 | 1.2 (0.2 to 5.3) | >0.2 | 22 | 36 | 2.2 (0.5 to 7.8) | >0.2 |
Amygdala | 22 | 57 | 4.7 (0.7 to 33.4) | 0.03 | 22 | 45 | 3.0 (0.7 to 12.3) | 0.07 | 22 | 36 | 1.9 (0.5 to 6.9) | >0.2 |
Frontal cortex | 2 | 0 | Â | Â | 2 | 0 | Â | Â | 2 | 0 | Â | Â |
Temporal cortex | 2 | 0 | Â | Â | 2 | 8 | 4.0 (0.1 to 44.2) | >0.2 | 2 | 0 | Â | Â |
Parietal cortex | 3 | 29 | 11.1 (0.9 to 82.3) | <0.01 | 4 | 8 | 2.1 (0.04 to 18.5) | >0.2 | 4 | 7 | 1.8 (0.04 to 15.2) | >0.2 |
Hippocampus | 2 | 0 | Â | Â | 2 | 0 | Â | Â | 2 | 0 | Â | Â |
Entorhinal cortex | 6 | 0 | 2.1 (0.04 to 18.2) | >0.2 | 7 | 0 | Â | Â | 6 | 7 | 1.2 (0.02 to 9.1) | >0.2 |
Cingulate cortex | 3 | 14 | 5.4 (0.1 to 57.2) | >0.2 | 3 | 8 | 2.9 (0.05 to 27.1) | >0.2 | 3 | 7 | 2.4 (0.05 to 22.2) | >0.2 |