Table 1 Pathology subgroups based on α-synucleinopathy (AS) and severity of neurofibrillary tangle (NFT) pathology
From: Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly
Neuropathology group | Â | Criteria | Number |
|---|---|---|---|
No pathology | Â | No AS; Braak stages I-III NFT | 49 |
NFT only | Â | No AS; Braak stages IV-VI NFT | 43 |
AS | Â | At least 1 LB or LN in any region | 84 |
AS | + high NFT | AS + Braak stages IV-VI NFT | 32 |
AS | + low NFT | AS + Braak stages I-III NFT | 52 |
AS DLB | + high NFT | AS pattern consistent with DLB Consensus; Braak stages IV-VI NFT | 13 |
AS DLB | + low NFT | AS pattern consistent with DLB Consensus; Braak stages I-III NFT | 20 |
AS Amygdala-predominant | + high NFT | amygdala-predominant AS pattern: Braak stages IV-VI NFT | 9 |
AS Amygdala-predominant | + low NFT | amygdala-predominant AS pattern: Braak stages I-III NFT | 9 |
AS Other pattern | + high NFT | AS pattern not consistent with DLB consensus or amygdala-predominant AS; Braak stages IV-VI NFT | 10 |
AS Other pattern | + low NFT | AS pattern not consistent with DLB consensus or amygdala-predominant AS: Braak stages I-III NFT | 23 |