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Table 2 Comparison of four antibody pairs for sensitivity to detect three different synthetic amyloid-beta oligomer preparations on the MSD platform

From: A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

   1C22/3D6B 1C22/82E1B 3B3/3D6B 3B3/82E1B
ADDLs LoD 4.0 258.6 3.2 51.6
  LLoQ 18.7 598.6 37.4 74.7
(S26C)2 LoD 55.6 48.7 84.0 26.8
  LLoQ 187.0 390.0 390.6 390.6
DiY LoD 154.0 92.7 369.0 44.8
  LLoQ 601.0 390.6 1562.5 781.3
  1. ADDL, amyloid-beta-derived diffusible ligand; DiY, dityrosine; LLoQ, lower limit of reliable quantification; LOD, limit of detection; MSD platform. MSD Multi-Array (Meso Scale Discovery, Gaithersburg, MD, USA).