Alzheimer's Research & Therapy

Table 2 Comparison of four antibody pairs for sensitivity to detect three different synthetic amyloid-beta oligomer preparations on the MSD platform

From: A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

		1C22/3D6B	1C22/82E1B	3B3/3D6B	3B3/82E1B
ADDLs	LoD	4.0	258.6	3.2	51.6
	LLoQ	18.7	598.6	37.4	74.7
(S26C)₂	LoD	55.6	48.7	84.0	26.8
	LLoQ	187.0	390.0	390.6	390.6
DiY	LoD	154.0	92.7	369.0	44.8
	LLoQ	601.0	390.6	1562.5	781.3

ADDL, amyloid-beta-derived diffusible ligand; DiY, dityrosine; LLoQ, lower limit of reliable quantification; LOD, limit of detection; MSD platform. MSD Multi-Array (Meso Scale Discovery, Gaithersburg, MD, USA).

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