1C22/3D6 oligomer-specific ELISA on the Erenna platform specifically recognizes amyloid-beta oligomers, not monomers. (A) Amyloid-beta monomers show virtually no reactivity in the 1C22/3D6 oligomeric-specific enzyme-linked immunosorbent assay: 26,000-fold lower signal compared with oligomers. (B) Lowest end of the detection range in (A) expanded to visualize the minimal detection of monomers at very high concentrations. Dashed line at 111 on the y axis, signal of blank. ADDL, amyloid-beta-derived diffusible ligand. Erenna platform (Singulex, Alameda, CA, USA).