The relationship of weight change trajectory with medial temporal lobe atrophy in patients with mild Alzheimer’s disease: results from a cohort study

Table 5 Patient characteristics at baseline: left MTA score of 0 or 1 versus 2, 3 or 4

	MTA score 0 or 1	MTA score 2, 3, 4	P
Age (year): n, median [25^th -75^th percentile]	16, 75.0 [72.0 - 78.8]	198, 79.0 [75.8 - 82.0]	0.003^b**
Women, n (%)	11 (68.8)	121 (61.1)	ns^c
Social status
alone, n (%)	10 (62.5)	83 (43.5)	ns^c
with partner, n (%)	5 (31.3)	103 (53.9)
other*, n (%)	1 (6.3)	5 (2.6)
CIRS (score): n, median [25^th -75^th percentile]	16, 5.0 [4.0 - 6.0]	198, 6.0 [4.0 - 8.0]	ns^b
Polypharmacy, n (%)	8 (50.0)	105 (53.3)	ns^c
Use of informal care, n (%)	13 (81.3)	169 (85.8)	ns^d
Use of professional care, n (%)	6 (37.5)	93 (47.7)	ns^c
MMSE (score): n, median [25^th -75^th percentile]	16, 25.0 [23.0 - 26.8]	196, 23.0 [20.0 - 15.0]	0.017^b**
Clock-drawing test (score): n, median [25^th -75^th percentile]	15, 3.0 [1.0 - 4.0]	178, 3.0 [2.0 -5.0]	ns^b
Presence of BPS, n (%)	5 (31.3)	46 (23.8)	ns^d
Weight (kg): n, mean ± SD	16, 68 ± 12	198, 74 ± 12	ns^a
BMI (weight/(height)²): n, median [25^th -75^th percentile]	16, 25.7 [21.1 - 27.0]	187, 25.9 [23.5 - 29.1]	ns^b
Use of ONS, n (%)	0 (0.0)	1 (0.8)	ns^d
Appetite
good, n (%)	14 (87.5)	156 (93.4)	ns^d
poor, n (%)	2 (12.5)	11 (6.6)	ns^d
Self-reported weight loss, n (%)	2 (12.5)	26 (14.6)	ns^d

*Other, that is: with son or daughter, brother or sister; **significant, that is P <0.05. ^aIndependent sample t test; ^bMann-Whitney U test; ^cPearson chi-square test; ^dFisher’s exact.
MTA, medial temporal lobe atrophy; P, probability; n, number of patients; ns, not significant; CIRS, cumulative illness rating scale; MMSE, mini mental state examination; BPS, behavioral and psychological symptoms; SD, standard deviation; BMI, body mass index; ONS, oral nutritional supplement.

ISSN: 1758-9193