Sensitivity to change and prediction of global change for the Alzheimer’s Questionnaire

Table 4 AQ, FAQ, and MMSE mean change as predictors of global change in mild cognitive impairment, Alzheimer’s disease, cognitively normal cases, and all groups combined

Group	Instrument	FAST increase	GDS increase	CDR Global score increase
aMCI
	AQ	1.07 (0.96, 1.20); P = 0.23	1.09 (0.97, 1.22); P = 0.15	1.09 (0.97, 1.24); P = 0.16
	FAQ	1.07 (0.96, 1.19); P = 0.25	0.97 (0.87, 1.08); P = 0.52	1.08 (0.96, 1.22); P = 0.22
	MMSE	1.02 (0.83, 1.26); P = 0.83	0.81 (0.64, 1.02); P = 0.07	0.91 (0.72, 1.15); P = 0.43
AD
	AQ	1.17 (0.97, 1.29); P = 0.14	1.26 (1.05, 1.52); P = 0.01	1.16 (1.00, 1.35); P = 0.06
	FAQ	1.09 (0.95, 1.24); P = 0.22	1.17 (1.00, 1.38); P = 0.05	1.12 (0.97, 1.29); P = 0.12
	MMSE	0.93 (0.77, 1.14); P = 0.50	0.97 (0.79, 1.19); P = 0.77	0.91 (0.74, 1.11); P = 0.35
CN
	AQ	1.09 (0.93, 1.28); P = 0.29	1.04 (0.88, 1.23); P = 0.67	1.26 (1.00, 1.59); P = 0.05
	FAQ	0.91 (0.68, 1.22); P = 0.52	1.02 (0.77, 1.34); P = 0.92	1.61 (1.10, 2.36); P = 0.02
	MMSE	0.88 (0.66, 1.17); P = 0.38	0.94 (0.70, 1.25); P = 0.66	0.72 (0.35, 1.49); P = 0.37
All Groups Combined
	AQ	1.11 (1.03, 1.20); P = 0.008	1.08 (1.00, 1.16); P = 0.05	1.20 (1.09, 1.32); P <0.001
	FAQ	1.09 (1.01, 1.18); P = 0.03	1.16 (1.06, 1.26); P = 0.001	1.21 (1.11, 1.33); P <0.001
	MMSE	0.91 (0.81, 1.03); P = 0.15	0.84 (0.74, 0.95); P = 0.006	0.91 (0.74, 1.11); P = 0.35

Odds ratio (95% confidence interval); P-value; FDR significance level = 0.006; odds ratios indicate the association for a 1-point increase in AQ, FAQ, and MMSE change scores with FAST, GDS and CDR-GS score increase as the outcome. AD, Alzheimer’s disease; aMCI, amnestic mild cognitive impairment; AQ, Alzheimer’s Questionnaire; CI, confidence interval; CDR, Clinical Dementia Rating; CN, cognitively normal; FAQ, Functional Activities Questionnaire; FAST, Functional Assessment Staging Test; GDS, Global Deterioration Score; MMSE, Mini Mental State Exam; MoCA, Montreal Cognitive Assessment.

ISSN: 1758-9193