Immunoblotting of HSP27 in frontal cortex from FTLD and control cases. (A) Frontotemporal lobar degeneration transactive response DNA binding protein (FTLD-TDP), case 1. (B) FTLD-MAPT case 2. (C) FTLD-Pick case 3. (D) Control case 4. (E) Control case 5. Lane 1: Whole-cell lysate; lane 2: low salt fraction; lane 3: Triton X-100 fraction; lane 4: sarkosyl fraction; lane 5: urea fraction.