Figure 4
Insoluble Aβ and α-syn levels in controls, PDND, PDD and DLB. Box-and-whisker plots indicate the full range, interquartile range and median value in each group. Insoluble Aβ42 level was significantly higher in DLB than controls in all regions except the thalamus. It was also significantly higher in DLB than PDND or PDD in the midfrontal region but lower in the thalamus. In all regions except the midfrontal, the insoluble Aβ42 level was significantly higher in both PDND and PDD than controls. The insoluble Aβ40 level was significantly greater in midfrontal and cingulate cortex and thalamus in PDND, PDD and DLB than controls, and in the parahippocampus the level was significantly higher in DLB than in PDND or PDD but not controls. The total insoluble α-syn level was significantly higher in PDD than controls or PDND in midfrontal cortex and higher than in DLB or controls in the parahippocampus. Total insoluble α-syn in the cingulate cortex was significantly higher in DLB than in PDND or controls. No significant differences between groups were observed in the thalamus. Aβ, amyloid-β; DLB, dementia with Lewy bodies; PDD, Parkinson’s disease with dementia; PDND, Parkinson’s disease without dementia; α-syn, α-synuclein.