Correlation between Aβ and soluble pSer129 α-syn. Each point represents a separate case. The best-fit linear regression (solid lines) and 95% confidence intervals (interrupted lines) are superimposed. Only significant P-values (and associated correlation coefficients) are shown in the figure. Significant negative correlations between soluble Aβ42 and soluble pSer129 α-syn were found in the cingulate (CG) cortex and thalamus (TH). In contrast, a significant positive correlation was found between soluble Aβ42 and soluble pSer129 α-syn in the midfrontal (MF) cortex. Significant negative correlations were found between soluble Aβ40 and soluble pSer129 α-syn in the CG, parahippocampal (PH) cortex and TH. Significant negative correlations were also found between soluble pSer129 α-syn and insoluble Aβ42 in the MF cortex and TH. A significant positive correlation was observed between soluble pSer129 α-syn and insoluble Aβ40 in the PH cortex. Aβ, amyloid-β; pSer129 α-syn, alpha-synuclein phosphorylated at serine 129.