Association between cell-bound blood amyloid-β(1 - 40) levels and hippocampus volume

Table 3 Hippocampal volume partial correlations with and without including diagnostic category ^a

	Not including diagnostic category		Including diagnostic category
	Partial correlation	P-value	Partial correlation	P-value
Aβ^ln DA Aβ(1 - 40)	0.05	0.64	−0.01	0.92
Aβ^ln DA Aβ(1 - 42)	−0.08	047	−0.15	0.20
Aβ^ln TP Aβ(1 - 40)	0.03	0.78	0.01	0.92
Aβ^ln TP Aβ(1 - 42)	−0.01	0.37	−0.14	0.22
Aβ ^ln CP Aβ(1 - 40)*	−0.37	0.0007	−0.35	0.002
Aβ^ln CP Aβ(1 - 42)	−0.16	0.17	−0.2	0.07
Total Aβ1	−0.18	0.11	−0.24	0.03
ADNI Aβ^ln Aβ(1 - 40)	0.08	0.05	0.1	0.01
ADNI Aβ^ln Aβ(1 - 42)	0.08	0.04	0.09	0.02

^aADNI: Alzheimer’s Disease Neuroimaging Initiative; Aβ: Amyloid-β; CP: Cellular pellet; DA: Directly accessible. The data are derived from the AB128 and ADNI data sets and represent partial correlations of Aβ blood levels with left hippocampal volume adjusted for the covariates age, gender, ApoE, education, creatinine levels and phenotype. The left columns show the correlations and P-values if phenotype is excluded as covariate. ADNI Aβ^ln Aβ(1 - 40) and Aβ^ln Aβ(1 - 42) values are placed underneath their comparative quantities. *Bold text highlights the correlation of the Aβ^ln CP Aβ(1 - 40) fraction in the AB128 study.

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