Figure 3

Positron emission tomography measurements, cerebrospinal fluid amyloid beta 1-42 and episodic memory scores. Statistical parametric mapping analysis showing clusters with significant covariance between positron emission tomography measurements versus levels of cerebrospinal fluid (CSF) amyloid beta 1-42 (Aβ_1-42) and episodic memory scores measured by means of Rey Auditory Verbal Learning (RAVLtot) tests, using data from Alzheimer's disease and mild cognitive impairment patients, at threshold P < 0.001, uncorrected for multiple comparisons. (a) Areas with significant covariance between Pittsburgh Compound B (¹¹C-PIB) retention and concentrations of Aβ_1-42 in CSF. (b) Clusters with significant covariance between ¹¹C-PIB retention and scores in RAVLtot tests. (c) Significant clusters of covariance between regional cerebral glucose metabolism (rCMRglc) and scores in RAVLtot tests. Data from [54].