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Table 3 Association of senile plaque type with APOE, CLU, CR1 and PICALM genotypes

From: CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques

   SP Diffuse Primitive Classic Burnt out
  Valid N SP OR (95% CI) P-value Diffuse OR (95% CI) P-value Primitive OR (95% CI) P-value Classic OR (95% CI) P-value Burnt out OR (95% CI) P-value
APOEε4-1 388 88 (22.7) - - 12 (3.1) - - 19 (4.9) - - 44 (11.3) - - 13 (3.4) - -
APOEε4+ 174 74 (42.5) 3.2 (2.05 to 4.90) <0.0001* 9 (5.2) 2.4 (0.97 to 5.86) 0.059 16 (9.2) 2.8 (1.37 to 5.74) 0.005* 37 (21.3) 3.2 (1.83 to 5.48) <0.0001* 12 (6.9) 3.8 (1.56 to 9.01) 0.003*
CLU TT2 336 89 (26.5) - - 13 (3.9) - - 22 (6.5) - - 48 (14.3) - - 6 (1.8) - -
CLU C+ 194 60 (30.9) 1.1 (0.73 to 1.76) 0.570 6 (3.1) 0.79 (0.29 to 2.14) 0.641 11 (5.7) 0.9 (0.39 to 1.84) 0.680 27 (13.9) 0.99 (0.56 to 1.77) 0.988 16 (8.2) 4.4 (1.61 to 12.2) 0.004*
CR1 AA2 186 56 (30.1) - - 8 (4.3) - - 9 (4.8) - - 28 (15.1) - - 11 (5.9) - -
CR1 C+ 361 102 (28.3) 0.9 (0.62 to 1.54) 0.924 12 (3.3) 0.71 (0.28 to 1.80) 0.475 24 (6.6) 1.2 (0.55 to 2.77) 0.611 53 (14.7) 0.85 (0.48 to 1.49) 0.572 13 (3.6) 0.57 (0.24 to 1.40) 0.221
PICALM CC2 219 71 (32.4) - - 7 (3.2) - - 19 (8.7) - - 37 (16.9) - - 8 (3.7) - -
PICALM T+ 327 87 (26.6) 0.6 (0.41 to 0.95) 0.028* 12 (3.7) 1.09 (0.42 to 2.84) 0.864 16 (4.9) 0.5 (0.26 to 1.09) 0.086 42 (12.8) 0.73 (0.42 to 1.25) 0.253 17 (5.2) 1.36 (0.55 to 3.39) 0.508
  1. Abbreviations: APOE , Apolipoprotein E; CI, confidence intervals; CLU , Clusterin; CR1, complement component (3b/4b) receptor 1; N, number of cases; OR, odds ratio; PICALM, phosphatidylinositol-binding clathrin assembly protein; SP, senile plaques; No SP was the reference group. Numbers in brackets are percentages, unless otherwise stated. In some cases it was impossible to obtain all variables due to technical difficulties and sample damage.
  2. * Denotes statistically significant values.
  3. 1 Denotes reference group used for statistical analyses. Age was used as a covariate.
  4. 2 Denotes most common homozygous genotype and used as the reference group for statistical analyses. APOEε4 carriership and age were used as covariates.