Skip to main content

Table 2 Parameters of the CSF biomarkers and their relations to cognitive impairment, above and below their change-points

From: Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study

CSF Biomarker 1-40 1-42 Tau Phospho-Tau
Cf change-point Above Below Above Below Above Below Above Below
Median 5,052 3,937** 682 350** 259 568** 50 80**
Variance 3,857,482 1,854,983** 36,846 71,482** 176,946 73,418** 1,700 1,000**
Spearman's ρ 0.21* -0.23* -0.24* -0.12 0.34** 0.28** 0.32** 0.16
Robust slope 93** -15** -0.048** -0.002 0.049* 0.004** 0.041** 0.004**
  1. The values in the first row are the raw biomarker levels (pg/mL); the second row shows the variance of the median-standardised levels; the third row shows Spearman's ρs for the rank correlations of biomarker levels with CAMCOG scores; the fourth row shows the slopes from the robust regressions of median-standardised biomarker levels. For each biomarker, the "Above" and "Below" columns shows values for CAMCOG scores above and below the change-point, respectively. Note that the correlations and slopes take cognitive impairment as the x-axis, which is the reverse of CAMCOG scores. Key:- (*): 0.10 >P > 0.05; *: P < 0.01; **: P < 0.01. For medians and variances, probabilities refer to the comparison of values above and below the change-point; for Spearman's ρ and slopes they refer to comparison of values with zero.