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Figure 5 | Alzheimer's Research & Therapy

Figure 5

From: Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease

Figure 5

Impaired lymphatic drainage of the brain in the pathogenesis of cerebral amyloid angiopathy (CAA) and Alzheimer disease (AD). The schema outlines a working hypothesis for the failure of perivascular lymphatic drainage of the brain with age and how such a failure contributes to the pathogenesis of CAA and AD. Aβ, amyloid-beta; ECS, extracellular spaces; ISF, interstitial fluid; NFT, neurofibrillary tangle.

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