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Table 1 Effect of statin therapy with simvastatin or atorvastatin on analytes in non-PSEN1 and PSEN1 subjects

From: Prevention of Alzheimer's disease in high risk groups: statin therapy in subjects with PSEN1 mutations or heterozygosity for apolipoprotein E epsilon 4

  Primary objective Drug effect Controlled for lipids
  Statins Atorvastatin Simvastatin Atorvastatin Simvastatin
Analyte % change P -value % change P -value % change P -value % change P -value % change P -value
Non-PSEN1           
   sAPPα 7 0.013 - NS 13.1 0.019 9.6 0.0082 23.7 0.0005
   sAPPβ - NS - NS - NS - NS - NS
   Phospho-tau - NS - NS - NS - NS - NS
   Total tau - NS - NS - NS - NS - NS
   AB42 - NS - NS - NS - NS - NS
PSEN1           
   sAPPα -16.5 0.0014 - NS -26.5 0.0002 - NS -24.1 0.0003
   sAPPβ -21.2 0.0005 - NS -31.5 0.0001 - NS - NS
   Phospho-tau -8.3 0.076 - NS - NS - NS - NS
   Total tau - NS - NS - NS - NS - NS
   AB42 - NS - NS - NS - NS - NS
  1. Aβ42 = amyloid-beta 42; NS, not significant; sAPP, soluble amyloid precursor protein.
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Alzheimer's Research & Therapy

ISSN: 1758-9193