|
Primary objective
|
Drug effect
|
Controlled for lipids
|
---|
|
Statins
|
Atorvastatin
|
Simvastatin
|
Atorvastatin
|
Simvastatin
|
---|
Analyte
|
% change
|
P -value
|
% change
|
P -value
|
% change
|
P -value
|
% change
|
P -value
|
% change
|
P -value
|
---|
Non-PSEN1
| | | | | | | | | | |
sAPPα
|
7
|
0.013
|
-
|
NS
|
13.1
|
0.019
|
9.6
|
0.0082
|
23.7
|
0.0005
|
sAPPβ
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
Phospho-tau
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
Total tau
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
AB42
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
PSEN1
| | | | | | | | | | |
sAPPα
|
-16.5
|
0.0014
|
-
|
NS
|
-26.5
|
0.0002
|
-
|
NS
|
-24.1
|
0.0003
|
sAPPβ
|
-21.2
|
0.0005
|
-
|
NS
|
-31.5
|
0.0001
|
-
|
NS
|
-
|
NS
|
Phospho-tau
|
-8.3
|
0.076
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
Total tau
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
AB42
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
-
|
NS
|
- Aβ42 = amyloid-beta 42; NS, not significant; sAPP, soluble amyloid precursor protein.