| Primary objective | Drug effect | Controlled for lipids | |||||||
---|---|---|---|---|---|---|---|---|---|---|
 | Statins | Atorvastatin | Simvastatin | Atorvastatin | Simvastatin | |||||
Analyte | % change | P -value | % change | P -value | % change | P -value | % change | P -value | % change | P -value |
Non-PSEN1 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   sAPPα | 7 | 0.013 | - | NS | 13.1 | 0.019 | 9.6 | 0.0082 | 23.7 | 0.0005 |
   sAPPβ | - | NS | - | NS | - | NS | - | NS | - | NS |
   Phospho-tau | - | NS | - | NS | - | NS | - | NS | - | NS |
   Total tau | - | NS | - | NS | - | NS | - | NS | - | NS |
   AB42 | - | NS | - | NS | - | NS | - | NS | - | NS |
PSEN1 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   sAPPα | -16.5 | 0.0014 | - | NS | -26.5 | 0.0002 | - | NS | -24.1 | 0.0003 |
   sAPPβ | -21.2 | 0.0005 | - | NS | -31.5 | 0.0001 | - | NS | - | NS |
   Phospho-tau | -8.3 | 0.076 | - | NS | - | NS | - | NS | - | NS |
   Total tau | - | NS | - | NS | - | NS | - | NS | - | NS |
   AB42 | - | NS | - | NS | - | NS | - | NS | - | NS |