Table 1 Human CSF proteins displaying differential expression in AD patients
Spot number | Protein name/Protein ID/Uniprot Accession Number/RefSeq | 33 N versus 33D | 33 N versus 44D | N versus D | Molecular weight | pI |
|---|---|---|---|---|---|---|
429 | Serum albumin, Chain A; ALBU_HUMAN P02768/NP_000468.1 | -1.29 | -1.37 | -1.33 | 69,366.68 | 5.92 |
P = 0.00034 | ||||||
541 | Transferrin variant; Q53H26_HUMAN Q53H26 /IP|00022463 | -1.53 | -1.50 | -1.51 | 77,079.85 | 6.68 |
P = 0.0011 | ||||||
575 | alpha 1-B glycoprotein; A1BG_HUMAN P04217/NP_570602.2 | -1.22 | -1.18 | -1.20 | 54,272.56 | 5.58 |
P = 0.0013 | ||||||
579 | alpha 1-B glycoprotein; A1BG_HUMAN P04217/NP_570602.2 | -1.31 | -1.31 | -1.31 | 54,272.56 | 5.56 |
P = 0.0015 | ||||||
614 | Transferrin variant; Q53H26_HUMAN Q53H26/IP|00022463 | +1.70 | +1.64 | +1.67 | 770,79.85 | 7.04 |
P = 0.0024 | ||||||
990 | Apolipoprotein H (beta-2-glycoprotein I) APOH_HUMAN P02749/NP_000033.2 | +1.67 | +1.60 | +1.63 | 38,298.16 | 8.34 |
P = 0.0021 | ||||||
1000 | Tubulin beta-2A chain; TBB2A_HUMAN Q13885/NP_001060.1 | +1.29 | +1.73 | +1.51 | 49,906.67 | 4.78 |
P = 0.0058 | ||||||
1008 | Keratin, type II cytoskeletal 1; K2C1_HUMAN P04264/NP_006112.3 | +2.94 | +2.62 | +2.77 | 66,038.73 | 8.15 |
P = 0.002 | ||||||
1017 | alpha-1-antitrypsin (SerpinA1); A1AT_HUMAN P01009/NP_000286.3 | +1.86 | +2.26 | +2.06 P = 0.0021 | 46,739.55 | 5.37 |
1118 | Pigment epithelium-derived factor (SerpinF1); PEDF_HUMAN P36955/NP_002606.3 | +1.54 | +1.99 | +1.77 | 46,342.30 | 5.97 |
P = 7.4E-05 | ||||||
1188 | ALB protein (growth-inhibiting protein 20), Isoform 2; ALBU_HUMAN P02768/NP_000468.1 | +1.26 | +1.23 | +1.24 | 47,360.49 | 5.97 |
P = 0.0065 | ||||||
1268 | Glutamine synthetase; GLNA_HUMAN; P15104/NP_001028216.1 | -1.38 | -1.55 | -1.46 | 42,064.46 | 6.43 |
P = 0.0025 | ||||||
1278 | Creatine kinase B-type; KCRB_HUMAN; P12277/NP_001814.2 | -1.46 | -1.40 | -1.43 | 42,644.28 | 5.34 |
P = 0.0077 | ||||||
1324 | Fructose-bisphosphate aldolase A; ALDOA_HUMAN P04075/NP_000025.1 | -1.49 | -1.53 | -1.51 | 39,420.02 | 8.30 |
P = 0.0074 | ||||||
1332 | Aspartate aminotransferase, cytoplasmic; AATC_HUMAN; P17174/NP_002070.1 | -1.28 | -1.49 | -1.38 | 46,247.51 | 6.53 |
P = 0.0099 | ||||||
1363 | Aspartate aminotransferase, cytoplasmic; AATC_HUMAN; P17174/NP_002070.1 | -1.27 | -1.41 | -1.33 | 46,247.51 | 6.50 |
P = 0.0003 | ||||||
1451 | Glyceraldehyde-3-phosphate dehydrogenase G3P_HUMAN P04406/NP_002037.2 | -2.05 | -1.75 | -1.87 | 36,042.22 | 8.57 |
P = 0.0002 | ||||||
1454 | Glyceraldehyde-3-phosphate dehydrogenase G3P_HUMAN P04406/NP_002037.2 | -1.45 | -1.42 | -1.44 | 36,042.22 | 8.59 |
P = 0.013 | ||||||
1469 | Glyceraldehyde-3-phosphate dehydrogenase G3P_HUMAN P04406/NP_002037.2 | -1.58 | -1.52 | -1.55 | 36,042.22 | 8.63 |
P = 0.00094 | ||||||
1470 | Glyceraldehyde-3-phosphate dehydrogenase G3P_HUMAN P04406/NP_002037.2 | -1.80 | -1.72 | -1.75 | 36,042.22 | 8.67 |
P = 0.0005 | ||||||
1472 | Clusterin; Apolipoprotein J; Complement-associated protein SP-40; CLUS_HUMAN; P10909/NP_001164609.1 | +2.01 | +2.01 | +2.01 | 50,062.56 | 5.89 |
P = 5.10E-05 | ||||||
1521 | Apolipoprotein E4; APOE_HUMAN P02649/NP_000032.1 | +2.14 | +3.34 | +2.74 | 36,154.08 | 5.65 |
P = 0.00023 | ||||||
1523 | Clusterin; Apolipoprotein J; Complement associated protein SP-40; CLUS_HUMAN; P10909/NP_001164609.1 | +1.78 | +2.17 | +1.97 | 50,062.56 | 5.89 |
P = 3.50E-06 | ||||||
1527 | Apolipoprotein E4; APOE_HUMAN P02649/NP_000032.1 | +2.02 | +2.42 | +2.22 | 36,154.08 | 5.65 |
P = 1.30E-05 | ||||||
1535 | Complement component 4A; C4A; Q5JNX2_HUMAN; Q5JNX2/IP|00643525 | +1.85 | +1.94 | +1.89 | ~3,5000 | 6.43 |
P = 7.10E-05 | ||||||
1554 | Transthyretin; TTHY_HUMAN; P02766/NP_000362.1 | +2.05 | +2.58 | +2.32 | 15,887.03 | 5.52 |
P = 0.00078 | ||||||
1779 | Ig Kappa chain C region; IGKC; IGKC_HUMAN; P01834/IP|00909649 | -1.98 | -2.14 | -2.06 | 11,608.86 | 5.58 |
P = 0.0061 | ||||||
1845 | Prostaglandin-H2 D-isomerase; cerebrin-28; PTGDS_HUMAN; P41222/NP_000945.3 | +1.45 | +1.51 | +1.48 | 21,028.82 | 7.66 |
P = 0.0077 | ||||||
1912 | Apolipoprotein A-1; ApoA1; APOA1-HUMAN; P02647/NP_000030.1 | -1.78 | -1.84 | -1.81 | 30,777.83 | 5.56 |
P = 0.0037 | ||||||
1982 | Superoxide dismutase [Mn], mitochondrial; SODM_HUMAN; P04179/NP_000627.2 | +1.66 | +1.62 | +1.64 | 24,722.09 | 8.35 |
P = 0.0011 | ||||||
2067 | Apolipoprotein A-1; ApoA1; APOA1-HUMAN; P02647/NP_000030.1 | -1.95 | -2.09 | -2.02 | 30,777.83 | 5.56 |
P = 7.40E-06 | ||||||
2068 | Apolipoprotein A-1; ApoA1; APOA1-HUMAN; P02647/NP_000030.1 | -2.25 | -2.24 | -2.24 | 30,777.83 | 5.56 |
P = 0.00035 |