Figure 1

Alzheimer’s Research UK (ARUK) research strategy to support the delivery of effective dementia treatments. ARUK funding will continue to support infrastructure and basic to clinical research, and a quarter of this funding will be focused on supporting targeted research into aspects of amyloid-beta biology, tau biology, neuronal death, and mechanisms underpinning the transmission of pathological protein conformers. Funding for the first critical phases of drug discovery will be provided through the Dementia Consortium (http://www.dementiaconsortium.org) and the ARUK Drug Discovery Institute, the latter of which is now being established. A longitudinal study of patients with Alzheimer’s disease (AD) will aim to define early changes and disease trajectory which will eventually help with clinical diagnosis and trial design.