Distribution and percentage of the AD and NAD patients between the different classes. (A, B) The mean (±SD) was plotted of the distribution of the AD (A) and NAD (B) patients in the Paris, Lille, and Montpellier cohorts and across the four classes based on the logistic regression or the PLM scale. Significant differences (Student t test) were found between the percentage of AD patients in classes 2 and 3 (A), as well as between the percentage of NAD patients in classes 0 and 1 (B). (C) The mean (±SD) of the percentage of AD patients in each class was plotted. No significant difference was apparent. (D, E) The distribution of AD (dark gray bars) and NAD (light gray bars) patients in the populations of the Rouen, Strasbourg, and Besançon (RSB) centers. The percentage of AD in each class is also plotted (black dots linked a dotted line). Data obtained by using the PLM scale (C) show more AD patients in class 3 and NAD in class 0 than for the logistic regression (E).