Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment

Table 4 Association of cerebrospinal fluid complement biomarkers with baseline and longitudinal changes (biomarker × time) in cognitive scores: mild cognitive impairment subjects

Model	Predictor	ADAS-Cog		MMSE		Memory		Executive function
Model	Predictor	β	P value	β	P value	β	P value	β	P value
C3	C3	−0.061	1.0	−0.062	1.0	−0.050	1.0	0.20	0.18
C3	C3 × time	−0.12	0.041	0.40	0.16	0.067	0.051	0.028	0.70
FH	FH	−0.077	1.0	−0.17	1.0	−0.014	1.0	0.077	0.29
FH	FH × time	−0.075	0.041	0.29	0.15	0.037	0.089	0.26	0.51
C3/FH	C3/FH	0.076	1.0	0.49	1.0	−0.13	1.0	0.41	0.18
C3/FH	C3/FH × time	−0.18	0.057	0.34	0.44	0.10	0.089	−0.0013	0.98

Age, gender (male reference category), education, total tau/amyloid β peptide 1–42 ratio and apolipoprotein E epsilon 4 allele presence adjusted mixed-effects model. P values are corrected for multiple comparisons (Holms). ADAS-Cog, Alzheimer’s disease Assessment Scale – cognitive subscale; C3, complement 3; FH, factor H; MMSE, Mini-Mental State Examination.

ISSN: 1758-9193