Skip to main content

Table 1 Summary findings in DLB compared to AD, PDD and HC

From: Neuroimaging characteristics of dementia with Lewy bodies

Comparisons with DLB Structural imaging: MRI and DTI Molecular and functional imaging: SPECT, PET, and fMRI Metabolic differences: MRS
AD Relatively preserved MTL volume in DLB compared to AD Significant reduction in FP-CIT binding in caudate and putamen compared to AD Normal levels of NAA/Cr and myo-inositol levels in DLB compared to AD
`Smaller substantia innominata and putamen in DLB compared to AD Hypometabolism in occipital cortex and visual association, preservation of posterior cingulate
A greater posterior predominance of FA change in DLB as opposed to a more diffuse pattern of change in AD Lower levels of amyloid deposition compared to AD
Reduced FA in the pons and the left thalamus in DLB compared to AD DLB patients show increased connectivity of the DMN in DLB compared to AD
Greater activation of the superior temporal sulcus in DLB compared to AD during a fMRI motor task
PDD More pronounced atrophy in DLB in the temporal, occipital and parietal lobes Increased amyloid deposition in DLB compared to PDD  
HC Reduced GM in temporal, parietal, occipital, and subcortical structures in DLB when compared to HC DLB show significant reduction in FP-CIT binding in caudate and putamen compared to HC Reduced white matter NAA/Cr in DLB compared to HC
   Increased Cho/Cr ratios in DLB compared to HC
Reduced FA in parieto-occipital white matter tracts in DLB compared to HC Hypometabolism in occipital cortex in DLB compared to HC  
Compared to HC, DLB patients show preservation of functional activity associated with lower visual areas
   Decreased V5/MT functional activity in response to motion stimuli is found in DLB compared to HC  
  1. AD, Alzheimer’s disease; Cho, choline; Cr, creatine; DLB, dementia with Lewy bodies; DMN, default mode network; DTI, diffusion tensor imaging; FA, fractional anisotropy; fMRI, functional magnetic resonance imaging; GM, gray matter; HC, healthy controls; MRI, magnetic resonance imaging; MRS, magnetic resonance spectroscopy; MT, middle temporal; MTL, medial temporal lobe; NAA, N-acetylaspartate; PDD, Parkinson’s disease dementia; PET, positron emission tomography; SPECT, single-photon emission computed tomography.