Table 1 Summary findings in DLB compared to AD, PDD and HC

AD

Relatively preserved MTL volume in DLB compared to AD

Significant reduction in FP-CIT binding in caudate and putamen compared to AD

Normal levels of NAA/Cr and myo-inositol levels in DLB compared to AD

`Smaller substantia innominata and putamen in DLB compared to AD

Hypometabolism in occipital cortex and visual association, preservation of posterior cingulate

A greater posterior predominance of FA change in DLB as opposed to a more diffuse pattern of change in AD

Lower levels of amyloid deposition compared to AD

Reduced FA in the pons and the left thalamus in DLB compared to AD

DLB patients show increased connectivity of the DMN in DLB compared to AD

Greater activation of the superior temporal sulcus in DLB compared to AD during a fMRI motor task

PDD

More pronounced atrophy in DLB in the temporal, occipital and parietal lobes

Increased amyloid deposition in DLB compared to PDD

HC

Reduced GM in temporal, parietal, occipital, and subcortical structures in DLB when compared to HC

DLB show significant reduction in FP-CIT binding in caudate and putamen compared to HC

Reduced white matter NAA/Cr in DLB compared to HC

Increased Cho/Cr ratios in DLB compared to HC

Reduced FA in parieto-occipital white matter tracts in DLB compared to HC

Hypometabolism in occipital cortex in DLB compared to HC

Compared to HC, DLB patients show preservation of functional activity associated with lower visual areas

Decreased V5/MT functional activity in response to motion stimuli is found in DLB compared to HC