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Table 4 Benefits and challenges of the active immunotherapies for alzheimer’s disease

From: Active immunotherapy options for Alzheimer’s disease

Advantages  Natural immune response
 Persistent amyloid-beta protein antibody titer levels
 Infrequent re-administrations
 Suitable for long-term therapy
 Good compliance
 Reduced cost
 Low antigen dose
 Potential polyclonal response
 Peak titers are reached gradually
 Avidity maturation of antibodies
 Reduced risk of anaphylaxis reactions
Disadvantages Challenges
 Relies on patients’ own immune response
 Autoreactive T-cell responses need to be avoided
 An understanding of the relationship of responses to clinical outcomes is required
 Generation of antibody responses in older patients
 Development of tolerance to be avoided
 Risk of developing an autoimmune response
 Risk of developing amyloid-related imaging abnormalities