Table 1 Summary of results
From: Amyloid-beta 42 adsorption following serial tube transfer
Analyte | Pool type | Linear regression (four transfers) | Confidence interval | P | % change | Linear regression (seven transfers) | Confidence interval | P | % change |
|---|---|---|---|---|---|---|---|---|---|
(Pilot) | Neat AD | −36.2 | −47.2 to −25.1 | 0.002 | 27.0% | ||||
Tween Ad | −9.9 | −16.6 to −3.2 | 0.018 | 5.1% | |||||
Aβ42 (Single-plex) | Neat CTRL | −72.1 | −78.4 to −65.8 | <0.005 | 28.6% | ||||
Tween CTRL | −27.2 | −70.7 to 16.3 | 0.140 | 4.9% | |||||
(Pilot) | Neat AD | −93.8 | −194.9 to 7.3 | 0.060 | 5.1% | ||||
Tween Ad | 14.2 | −94.7 to 123.1 | 0.706 | 0.4% | |||||
T-tau | Neat CTRL | −34.5 | −73.3 to 4.3 | 0.066 | 5.8% | ||||
Tween CTRL | −14.8 | −38.8 to 10.0 | 0.157 | 1.6% | |||||
(Replication) | Neat AD | −50.2 | −62.6 to −37.9 | <0.005 | 21.8% | −34.3 | −40.6 to −28.3 | <0.005 | 21.1% |
Tween Ad | −22.1 | −31.3 to −12.9 | <0.005 | 6.1% | −25.2 | −29.5 to −20.9 | <0.005 | 7.8% | |
Aβ42 (Single-plex) | Neat CTRL | −83.3 | −110.0 to −56.5 | <0.005 | 25.6% | −52.2 | −64.8 to −39.7 | <0.005 | 22.7% |
Tween CTRL | −9.8 | −22.8 to 3.2 | 0.126 | 1.9% | −34 | −44.9 to −23.1 | <0.005 | 8.0% | |
(Replication) | Neat AD | −16.9 | −31.7 to −2.2 | 0.028 | 2.6% | −24.5 | −39.4 to −9.5 | 0.003 | 4.4% |
Tween Ad | 7.1 | −3.4 to 17.6 | 0.164 | −0.9% | −106 | −7.4 to 4.1 | 0.558 | 0.2% | |
T-tau | Neat CTRL | −3.35 | −11.6 to 4.9 | 0.338 | −0.1% | −11.6 | −17.4 to −5.9 | <0.005 | 3.5% |
Tween CTRL | 1.1 | −7.5 to 9.6 | 0.789 | −0.5% | −0.4 | −4.0 to 3.2 | 0.828 | 0.5% | |
(Replication) | Neat AD | −320.1 | −397.0 to −243.1 | <0.005 | 11.7% | −330.2 | −359.3 to −301.0 | <0.005 | 16.0% |
Tween Ad | −37.7 | −103.3 to 27.8 | 0.232 | 0.4% | −53.1 | −78.9 to −27.3 | <0.005 | 1.4% | |
Aβ38 (Triplex) | Neat CTRL | −215.9 | −262.5 to −169.3 | <0.005 | 11.7% | −224.0 | −241.8 to −206.3 | <0.005 | 16.1% |
Tween CTRL | 5.1 | −16.2 to 26.4 | 0.608 | −0.3% | −38.4 | −53.5 to −23.4 | <0.005 | 1.1% | |
(Replication) | Neat AD | −669.9 | −786.7 to −552.9 | <0.005 | 12.1% | −676.5 | −724.7 to −628.2 | <0.005 | 15.6% |
Tween Ad | 15.3 | −66.7 to 97.4 | 0.689 | −0.6% | −121.5 | −174.7 to −68.4 | <0.005 | 1.2% | |
Aβ40 (Triplex) | Neat CTRL | −55.1 | −652.1 to −449.9 | <0.005 | 14.5% | −513.3 | −554.0 to −472.7 | <0.005 | 17.5% |
Tween CTRL | −20.5 | −76 to 35 | 0.434 | 0.1% | −112.9 | −152.2 to −73.6 | <0.005 | 1.6% | |
(Replication) | Neat AD | −47.7 | −61.6 to −33.8 | <0.005 | 21.0% | −34.9 | −40.9 to −28.8 | <0.005 | 22.2% |
Tween Ad | −10.9 | −18.7 to −3.2 | 0.010 | 1.9% | −17.3 | −20.7 to −13.9 | <0.005 | 4.9% | |
Aβ42 (Triplex) | Neat CTRL | −74.6 | −99.0 to −50.2 | <0.005 | 23.1% | −41.4 | −62.0 to −40.9 | <0.005 | 23.4% |
Tween CTRL | −19.6 | −27.0 to −12.2 | <0.005 | 3.1% | −28.1 | −32.6 to −23.7 | <0.005 | 5.5% |