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Table 1 Summary of results

From: Amyloid-beta 42 adsorption following serial tube transfer

Analyte Pool type Linear regression (four transfers) Confidence interval P % change Linear regression (seven transfers) Confidence interval P % change
(Pilot) Neat AD −36.2 −47.2 to −25.1 0.002 27.0%     
Tween Ad −9.9 −16.6 to −3.2 0.018 5.1%     
Aβ42 (Single-plex) Neat CTRL −72.1 −78.4 to −65.8 <0.005 28.6%     
Tween CTRL −27.2 −70.7 to 16.3 0.140 4.9%     
(Pilot) Neat AD −93.8 −194.9 to 7.3 0.060 5.1%     
Tween Ad 14.2 −94.7 to 123.1 0.706 0.4%     
T-tau Neat CTRL −34.5 −73.3 to 4.3 0.066 5.8%     
Tween CTRL −14.8 −38.8 to 10.0 0.157 1.6%     
(Replication) Neat AD −50.2 −62.6 to −37.9 <0.005 21.8% −34.3 −40.6 to −28.3 <0.005 21.1%
Tween Ad −22.1 −31.3 to −12.9 <0.005 6.1% −25.2 −29.5 to −20.9 <0.005 7.8%
Aβ42 (Single-plex) Neat CTRL −83.3 −110.0 to −56.5 <0.005 25.6% −52.2 −64.8 to −39.7 <0.005 22.7%
Tween CTRL −9.8 −22.8 to 3.2 0.126 1.9% −34 −44.9 to −23.1 <0.005 8.0%
(Replication) Neat AD −16.9 −31.7 to −2.2 0.028 2.6% −24.5 −39.4 to −9.5 0.003 4.4%
Tween Ad 7.1 −3.4 to 17.6 0.164 −0.9% −106 −7.4 to 4.1 0.558 0.2%
T-tau Neat CTRL −3.35 −11.6 to 4.9 0.338 −0.1% −11.6 −17.4 to −5.9 <0.005 3.5%
Tween CTRL 1.1 −7.5 to 9.6 0.789 −0.5% −0.4 −4.0 to 3.2 0.828 0.5%
(Replication) Neat AD −320.1 −397.0 to −243.1 <0.005 11.7% −330.2 −359.3 to −301.0 <0.005 16.0%
Tween Ad −37.7 −103.3 to 27.8 0.232 0.4% −53.1 −78.9 to −27.3 <0.005 1.4%
Aβ38 (Triplex) Neat CTRL −215.9 −262.5 to −169.3 <0.005 11.7% −224.0 −241.8 to −206.3 <0.005 16.1%
Tween CTRL 5.1 −16.2 to 26.4 0.608 −0.3% −38.4 −53.5 to −23.4 <0.005 1.1%
(Replication) Neat AD −669.9 −786.7 to −552.9 <0.005 12.1% −676.5 −724.7 to −628.2 <0.005 15.6%
Tween Ad 15.3 −66.7 to 97.4 0.689 −0.6% −121.5 −174.7 to −68.4 <0.005 1.2%
Aβ40 (Triplex) Neat CTRL −55.1 −652.1 to −449.9 <0.005 14.5% −513.3 −554.0 to −472.7 <0.005 17.5%
Tween CTRL −20.5 −76 to 35 0.434 0.1% −112.9 −152.2 to −73.6 <0.005 1.6%
(Replication) Neat AD −47.7 −61.6 to −33.8 <0.005 21.0% −34.9 −40.9 to −28.8 <0.005 22.2%
Tween Ad −10.9 −18.7 to −3.2 0.010 1.9% −17.3 −20.7 to −13.9 <0.005 4.9%
Aβ42 (Triplex) Neat CTRL −74.6 −99.0 to −50.2 <0.005 23.1% −41.4 −62.0 to −40.9 <0.005 23.4%
Tween CTRL −19.6 −27.0 to −12.2 <0.005 3.1% −28.1 −32.6 to −23.7 <0.005 5.5%
  1. The table summarises the results of linear regression and percentage difference calculations for all analytes assayed in this study. Linear regression used the median values of the measurements made at each transfer step. ‘% change’ represents the average of the percentage difference between each of the relevant number of transfer steps. Bold text is used as a visual aid and has no other meaning. Aβ, amyloid beta; AD, Alzheimer’s disease; CTRL, control, T-tau, total tau.