Figure 3

Stage II chronic traumatic encephalopathy. In stage II chronic traumatic encephalopathy, there is spread of pathology from focal epicenters (A) to the superficial layers of adjacent cortex (B). The nucleus basalis of Meynert (C) shows moderate neurofibrillary tangles and neurites. The medial temporal lobe shows only mild neurofibrillary pathology, including the amygdala (D) and CA1 of the hippocampus (E). CP-13-immunostained 50 μm tissue sections, some counterstained with cresyl violet. Scale bar = 100 μm. Adapted from [29].