Neuropathologic inclusions seen in tauopathies range from intracellular to extracellular and from neuron to glia. Alzheimer’s disease neuropathologic inclusions used to classify severity based on an ABC scoring scheme include (a) extracellular amyloid-beta (Aβ) plaque (33.1.1 antibody), (b) neurofibrillary tangle (NFT) composed of abnormal tau fibrils (paired helical filament phosphorylated tau antibody), and (c) Aβ deposits surrounded by dystrophic neurites produce neuritic plaques (observed with Bielschowsky silver stain). Tau immunohistochemistry in progressive supranuclear palsy shows abnormal tau aggregates in (d) astrocytes called tufts or tufted astrocytes, (e) neurons called globose NFTs, and (f) oligodendrocytes termed coiled bodies. Tau-immunoreactivity in corticobasal degeneration (CBD) shows abnormal tau aggregates in (g) astrocytes called astrocytic plaques and tau-immunoreactive threads in the gray and white matter in neocortical and subcortical regions and (h) swollen, achromatic or ballooned neurons (hematoxylin and eosin). (i) Tau-immunoreactive, dense spherical neuronal cytoplasmic inclusions called Pick bodies are observed in granular neurons of the dentate fascia in Pick’s disease. (a), (b), (c) Medial temporal cortex. (d), (e), (f),(g), (i) Phospho-tau antibody CP13. (d), (f) Red nucleus at the level of the oculomotor nerve. (e) Substantia nigra. (g), (h) Mid-frontal cortex.