Hippocampal and neocortical caspase-3 activity. Caspase-3 activity was revealed by a fluorometric assay in total hippocampal and neocortical homogenates from sham and lesioned rats (n = 3/group). The fluorometric data are expressed as mean ± SEM. *P < 0.05, ***P ≤ 0.001 (Bonferroni multiple comparisons test). Don-Sap, donepezil-treated Sap-lesioned rats; Don-Sham, donepezil-treated sham-lesioned rats; Sal-Sap, saline-treated Sap-lesioned rats; Sal-Sham, saline-treated sham-lesioned rats.