Variable | 2 months | 6 months | 12 months | 18 months | 24 months | 30 months | 36 months |
---|---|---|---|---|---|---|---|
(n= 706) | (n= 662) | (n= 597) | (n= 521) | (n= 450) | (n= 374) | (n= 306) | |
Completion rate (%) | 96.2 | 90.2 | 81.3 | 71.0 | 61.3 | 51.0 | 41.7 |
MMSE scorea | 24.0 (23.8, 24.2) | 23.5 (23.3, 23.8) | 22.8 (22.5, 23.2) | 22.1 (21.7, 22.5) | 21.4 (20.9, 21.8) | 21.1 (20.5, 21.6) | 20.6 (20.0, 21.2) |
ADAS-cog (0 to 70) scorea | 17.4 (16.8, 18.0) | 18.3 (17.6, 19.0) | 19.5 (18.6, 20.3) | 20.1 (19.1, 21.1) | 21.3 (20.0, 22.7) | 21.7 (20.2, 23.2) | |
IADL scorea | 15.8 (15.4, 16.2) | 17.0 (16.6, 17.5) | 17.9 (17.4, 18.5) | 18.8 (18.2, 19.4) | 19.4 (18.7, 20.1) | 19.8 (19.1, 20.6) | |
MMSE score, change from baselinea | 0.61 (0.43, 0.78) | 0.19 (−0.04, 0.42) | −0.57 (−0.86, −0.28) | −1.31 (−1.66, −0.96) | −2.20 (−2.64, −1.77) | −2.54 (−3.06, −2.02) | −3.10 (−3.66, −2.54) |
ADAS-cog (0 to 70) score, change from baselinea | −0.15 (−0.65, 0.34) | −1.20 (−1.77, −0.63) | −2.58 (−3.27, −1.90) | −3.81 (−4.59, −3.03) | −4.97 (−6.09, −3.85) | −6.12 (−7.35, −4.89) | |
IADL score, change from baselinea | −1.12 (−1.34, −0.91) | −2.48 (−2.78, −2.17) | −3.64 (−4.01, −3.26) | −4.75 (−5.18, −4.33) | −5.54 (−6.06, −5.02) | −6.27 (−6.86, −5.68) | |
MMSE score, improved/unchanged patients (%) | 72.7 | 64.1 | 55.0 | 46.9 | 41.9 | 38.2 | 33.0 |
ADAS-cog (0 to 70) score, improved/unchanged patients (%) | 55.3 | 48.8 | 41.8 | 36.7 | 32.9 | 31.1 | |
IADL score, improved/unchanged patients (%) | 49.7 | 34.2 | 24.3 | 18.0 | 14.8 | 13.8 |