Episodic memory encoding
|
↓ activation in MTL
|
↓ adaptive attenuation of hippocampus activation with repeated exposure
|
|
↑ activatio n in right DLPFC, left VLPFC, left OFC, superior temporal gyri, fusiform gyri, and left thalamus
|
↓ activation in MTL structures and in bilateral frontal regions in well-characterized amnestic MCI
|
|
↓ activation cingulate, right mPFC, right insula, right superior parietal lobule, and left precuneus
|
Delayed BOLD response
|
| |
↑ MTL activation in early MCI patients who had comparable task performance with controls, extent of MTL activity positively correlated with successful encoding
|
| |
Greater MTL functional MRI activation at baseline predicted conversion to Alzheimer's disease
|
| |
↑ activation in posterior hippocampus and parahippocampal and fusiform regions, together with atrophy of more anterior MTL
|
Episodic memory retrieval
|
↓ activation in MTL
|
↑ activity in PCC
|
|
↑ activation in right DLPFC and left VLPFC, left supramarginal, and left precuneus, and right thalamus
|
↓ activity in bilateral frontal regions and left hippocampus
|
|
↓ activation in left claustrum/amygdala, and bilateral insula
| |