Regulation of distinct pools of amyloid β-protein by multiple cellular proteases

Table 1 Examples of amyloid β-protein-degrading proteases with distinct localization profiles

Plus sign indicates present and proteolytically active, and minus sign indicates present but not active (inactivity is due to pH or other factors); (+) indicates mixed evidence for activity. AβDP, amyloid β-protein-degrading protease; CatB, cathepsin B; CatD, cathepsin D; ECE, endothelin-converting enzyme; ER, endoplasmic reticulum; IDE, insulin-degrading enzyme; NEP, neprilysin; PreP, presequence protease.

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