Figure 2

TREM2 immunohistochemistry of spleen, bone marrow, and brain tissues. The panels represent (a) normal control, spleen, HPA010917; (b) normal control, bone marrow (L1), HPA010917; (c) Alzheimer's disease (AD), the frontal cortex, HPA010917 (brown) and HLADR (red); (d) AD, the frontal cortex, HPA010917 (brown) and CD68 (red); (e) AD, the frontal cortex, HPA010917; and (f) the same region as (e), HPA010917 absorbed by preincubation with recombinant TREM2 protein.