From: The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice
Screen | Company |
---|---|
Lead Profile Screen (60 CNS receptors/transporters) | Ricerca-MDS |
Protein Kinase Screen (50 kinases - activity) | Nova Screen |
Protein Kinase (352 kinases - binding) | Ambit |
All phosphatases (Tyr and Ser/Thr) | Caliper |
Known proteases | Caliper and Ricerca |
Deubiquitinases, Esterases, Secretases, Caspases | Caliper |
5-, 12-, 15-LOX, COX-1 and 2, NADPH oxidase | MDS |
Deacetylase, Sirtuin SIRT-1, -2, -3, Proteasome, MAO A and B | Ricerca |
All phosphodiesterases and 5-CYPs | MDS |