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Table 2 Final linear regression models of Lp-PLA2 activity by diagnosis group

From: Plasma lipoprotein-associated phospholipase A2 activity in Alzheimer's disease, amnestic mild cognitive impairment, and cognitively healthy elderly subjects: a cross-sectional study

 

Model Without LDL

Model With LDL

 

β (SE)†

P

β (SE)†

P

AD (versus Control)*

7.7 (7.2)

0.29

8.3 (5.7)

0.15

aMCI (versus Control)*

11.3 (7.2)

0.12

11.6 (5.8)

0.05

Age (1 year increase)*

-0.19 (0.3)

0.58

0.39 (0.3)

0.16

Statin use (yes versus no)*

-23.9 (7.0)

0.001

-11.2 (5.8)

0.06

Gender (female versus male)*

-10.6 (6.2)

0.09

-23.8 (4.9)

< .0001

LDL (1 mmol/l increase)

NA

NA

24.1 (2.5)

< .0001

BMI

1.8 (0.8)

0.03

0.4 (0.69)

0.55

Diabetes Type 2 (yes versus no)

-23.3 (14.0)

0.10

-2.7 (11.6)

0.81

  1. Final models selected through backwards elimination. Covariates with P- value < 0.05 are presented in bold. *Forced to remain in the model. † β estimates correspond to the expected difference in mean Lp-PLA2 activity relative to comparator for binary variables or per one unit increase in continuous covariates.
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Alzheimer's Research & Therapy

ISSN: 1758-9193