| |
Model Without LDL
|
Model With LDL
|
|---|
| |
β (SE)†
|
P
|
β (SE)†
|
P
|
|---|
|
AD (versus Control)*
|
7.7 (7.2)
|
0.29
|
8.3 (5.7)
|
0.15
|
|
aMCI (versus Control)*
|
11.3 (7.2)
|
0.12
|
11.6 (5.8)
|
0.05
|
|
Age (1 year increase)*
|
-0.19 (0.3)
|
0.58
|
0.39 (0.3)
|
0.16
|
|
Statin use (yes versus no)*
|
-23.9 (7.0)
|
0.001
|
-11.2 (5.8)
|
0.06
|
|
Gender (female versus male)*
|
-10.6 (6.2)
|
0.09
|
-23.8 (4.9)
|
< .0001
|
|
LDL (1 mmol/l increase)
|
NA
|
NA
|
24.1 (2.5)
|
< .0001
|
|
BMI
|
1.8 (0.8)
|
0.03
|
0.4 (0.69)
|
0.55
|
|
Diabetes Type 2 (yes versus no)
|
-23.3 (14.0)
|
0.10
|
-2.7 (11.6)
|
0.81
|
- Final models selected through backwards elimination. Covariates with P- value < 0.05 are presented in bold. *Forced to remain in the model. † β estimates correspond to the expected difference in mean Lp-PLA2 activity relative to comparator for binary variables or per one unit increase in continuous covariates.
