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Figure 7 | Alzheimer's Research & Therapy

Figure 7

From: Simulations of symptomatic treatments for Alzheimer's disease: computational analysis of pathology and mechanisms of drug action

Figure 7

Weekly correlation between Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog) outcomes and model predictions. (A) Correlation between changes in reported ADAS-Cog outcomes from 7 different therapeutic interventions at week 12 and their corresponding working memory effects in the computer model of Alzheimer's disease (P = 0.038). For the time points, the data show that even for individual time points there is a good correlation between clinical outcome and corresponding computer model outcome. (B) Correlation between reported ADAS-Cog outcomes from 12 different therapeutic interventions at week 26 and their corresponding working memory effects in the computer model of Alzheimer's disease (P = 0.042). (C) Correlation between reported ADAS-Cog outcomes from eight different therapeutic interventions at week 52 and their corresponding working memory effects in the computer model of Alzheimer's disease (P = 0.031).

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