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Table 3 Subcortical volumes in C9ORF72 mutation and healthy control groups

From: Longitudinal neuroimaging and neuropsychological profiles of frontotemporal dementia with C9ORF72 expansions

   C9ORF72 Control  
   % per year Atrophy (ml/year) SD % per year Atrophy (ml/year) SD P value
Thalamus Right 3.4 0.16 0.17 -0.2 -0.02 0.08 0.006
  Left 2.5 0.23 0.29 -0.3 -0.02 0.09 0.03
Globus pallidus Right 1.7 0.05 0.10 0.0 0.00 0.03 n/s
  Left 2.9 0.03 0.14 -1.1 -0.02 0.06 0.04
Caudate Right -2.6 -0.09 0.15 0.3 0.01 0.06 n/s
  Left 0.7 0.02 0.07 0.0 0.00 0.13 n/s
Amygdala Right -2.8 -0.04 0.08 0.1 0.00 0.04 n/s
  Left 2.1 0.03 0.06 0.6 0.01 0.06 n/s
Hippocampus Right 1.7 0.07 0.08 1.0 0.04 0.06 n/s
  Left 1.4 0.05 0.03 0.6 0.03 0.09 n/s
Putamen Right -0.6 -0.03 0.10 0.0 0.00 0.06 n/s
  Left -1.2 -0.06 0.13 -0.1 0.00 0.10 n/s
  1. Mean annualised rates of change are expressed as a percentage (%) and as the millilitre (ml) change from baseline. C9ORF72, chromosome 9 open reading frame 72; n/s, not significant p < 0.05; SD, standard deviation.