| | |
C9ORF72
|
Control
| |
|---|
| | |
% per year
|
Atrophy (ml/year)
|
SD
|
% per year
|
Atrophy (ml/year)
|
SD
|
P value
|
|---|
|
Thalamus
|
Right
|
3.4
|
0.16
|
0.17
|
-0.2
|
-0.02
|
0.08
|
0.006
|
| |
Left
|
2.5
|
0.23
|
0.29
|
-0.3
|
-0.02
|
0.09
|
0.03
|
|
Globus pallidus
|
Right
|
1.7
|
0.05
|
0.10
|
0.0
|
0.00
|
0.03
|
n/s
|
| |
Left
|
2.9
|
0.03
|
0.14
|
-1.1
|
-0.02
|
0.06
|
0.04
|
|
Caudate
|
Right
|
-2.6
|
-0.09
|
0.15
|
0.3
|
0.01
|
0.06
|
n/s
|
| |
Left
|
0.7
|
0.02
|
0.07
|
0.0
|
0.00
|
0.13
|
n/s
|
|
Amygdala
|
Right
|
-2.8
|
-0.04
|
0.08
|
0.1
|
0.00
|
0.04
|
n/s
|
| |
Left
|
2.1
|
0.03
|
0.06
|
0.6
|
0.01
|
0.06
|
n/s
|
|
Hippocampus
|
Right
|
1.7
|
0.07
|
0.08
|
1.0
|
0.04
|
0.06
|
n/s
|
| |
Left
|
1.4
|
0.05
|
0.03
|
0.6
|
0.03
|
0.09
|
n/s
|
|
Putamen
|
Right
|
-0.6
|
-0.03
|
0.10
|
0.0
|
0.00
|
0.06
|
n/s
|
| |
Left
|
-1.2
|
-0.06
|
0.13
|
-0.1
|
0.00
|
0.10
|
n/s
|
- Mean annualised rates of change are expressed as a percentage (%) and as the millilitre (ml) change from baseline. C9ORF72, chromosome 9 open reading frame 72; n/s, not significant p < 0.05; SD, standard deviation.
