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Figure 3 | Alzheimer's Research & Therapy

Figure 3

From: Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis

Figure 3

Amyloid-β plaque burden and conditioned fear memory in CRND8 mice. (A) The levels of amyloid-β burden (mean (%) ± SEM) significantly increased in CRND8 mice between the ages of three and 12 months. The progressing with age Aβ plaque burden was significantly associated with deterioration in (B) contextual (P < 0.05) and in (C) tone (P < 0.05) fear memory in CRND8 mice. ** P < 0.01, *** P < 0.001.

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Alzheimer's Research & Therapy

ISSN: 1758-9193