Skip to main content
Figure 2 | Alzheimer's Research & Therapy

Figure 2

From: Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice

Figure 2

LRP1 levels are reduced in hippocampal neurons of LRP1lox/lox mice that are transgenic for GFAP-Cre. Eight-month-old APPswe/PS1dE9 × GFAP-Cre × LRP1 lox/lox littermates were used for immunostaining. All mice were homozygous for LRP1loxp alleles and positive for APPswe/PS1dE9 transgenes. The presence or absence of GFAP-Cre is noted above the images. LRP1 α377 antibody (1:1,000, red) was used to stain LRP1; NeuN (1:1,000, green) was used to stain neurons; Dapi in the mounting reagent was used to display nuclei. Confocal microscope images showed most of the neurons in CA fields (A) and the dentate gyrus (C and E) of APPswe/PS1dE9 × LRP1lox/lox × GFAP-Cre mice do not exhibit LRP1 immunoreactivity. Control mice lacking the GFAP-Cre transgene showed intense staining of LRP1 in hippocampal neurons (B, D, and F). Three to four pairs of mice per genotype were used for immunostaining and four to five sections per animal were analyzed.

Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193