Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals

Table 3 Cox proportional hazard ratios for conversion to mild cognitive impairment or dementia

Characteristic	Subgroup	n	Hazards ratio	95% CI		P-value
Characteristic	Subgroup	n	Hazards ratio	Lower	Upper	P-value
Unadjusted model
Group	A − T +	60	1.85	0.96	3.55	.064
	A + T −	84	2.58	1.39	4.77	.003
	A + T +	46	4.03	2.17	7.49	< .001
Adjusted model
Group	A − T +	60	1.75	0.89	3.44	.106
	A + T −	84	2.38	1.26	4.48	.007
	A + T +	46	3.35	1.76	6.39	< .001
Age			1.06	1.02	1.11	.005
Male			1.54	0.94	2.51	.084
Years of education			0.94	0.87	1.02	.160
APOE ε4 alleles			2.19	0.96	5.00	.063
SMC			1.26	0.69	2.29	.446

ISSN: 1758-9193