Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals

Fujishima, Motonobu; Kawasaki, Yohei; Mitsuhashi, Toshiharu; Matsuda, Hiroshi

doi:10.1186/s13195-024-01450-7

Alzheimer's Research & Therapy

Table 2 Summary of a generalized linear mixed-effects model in the main analysis for serial structural MRI and cognitive performance measures from baseline to 7.5 years

From: Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals

	Whole brain			Lateral ventricle			Hippocampus
	β	95% CI	P-value	β	95% CI	P-value	β	95% CI	P-value
	β	Lower, Upper	P-value	β	Lower, Upper	P-value	β	Lower, Upper	P-value
Intercept	1353.323	1281.298, 1425.348	< .001	− 21.463	− 41.046, − 1.880	.032	11.707	10.577, 12.838	< .001
Age	− 4.239	− 5.108, − 3.370	< .001	0.767	0.532, 1.002	< .001	− 0.051	− 0.065, − 0.037	< .001
Male	16.673	4.900, 28.447	.006	− 1.893	− 5.077, 1.290	.244	0.102	− 0.083, 0.287	.280
Years of education	− 0.349	− 2.261, 1.563	.720	0.194	− 0.322, 0.710	.462	− 0.039	− 0.069, − 0.009	.012
APOE ε4 alleles	16.491	− 3.813, 36.795	.111	− 8.790	− 14.296, − 3.283	.002	0.083	− 0.236, 0.402	.609
Baseline ICV	0.541	0.504, 0.577	< .001	0.042	0.032, 0.052	< .001	0.003	0.002, 0.003	< .001
SMC	14.324	2.965, 25.682	.013	2.182	− 0.916, 5.280	.168	0.067	− 0.111, 0.245	.461
Group
A − T +	5.763	− 8.256, 19.782	.420	− 3.720	− 8.059, 0.619	.093	− 0.028	− 0.248, 0.192	.802
A + T −	− 16.684	− 29.442, − 3.925	.010	13.526	9.590, 17.462	< .001	− 0.168	− 0.368, 0.033	.101
A + T +	− 2.018	− 18.274, 14.238	.808	4.370	− 0.609, 9.350	.085	− 0.055	− 0.310, 0.200	.673
Time	− 5.878	− 6.450, − 5.306	< .001	1.239	1.072, 1.406	< .001	− 0.091	− 0.103, − 0.078	< .001
Group × time
A − T + × time	− 0.321	− 1.441, 0.800	.575	− 0.038	− 0.363, 0.287	.819	− 0.023	− 0.047, 0.002	.069
A + T − × time	− 0.524	− 1.548, 0.500	.316	0.757	0.463, 1.050	< .001	− 0.015	− 0.038, 0.007	.188
A + T + × time	− 2.782	− 4.060, − 1.504	< .001	0.889	0.523, 1.255	< .001	− 0.057	− 0.085, − 0.029	< .001
	Cortical thickness					PACC
	β	95% CI		P-value		β	95% CI		P-value
	β	Lower, Upper		P-value		β	Lower, Upper		P-value
Intercept	4.19	3.87, 4.51		< .001		6.65	3.52, 9.78		< .001
Age	− 0.02	− 0.02, − 0.01		< .001		− 0.13	− 0.17, − 0.09		< .001
Male	− 0.08	− 0.12, − 0.03		.001		− 1.21	− 1.65, − 0.77		< .001
Years of education	0.00	− 0.01, 0.01		.602		0.30	0.22, 0.39		< .001
APOE ε4 alleles	− 0.01	− 0.10, 0.08		.808		− 0.41	− 1.31, 0.48		.366
Baseline ICV	NA	NA		NA		NA	NA		NA
SMC	0.05	− 0.00, 0.10		.057		− 0.75	− 1.27, − 0.23		.005
Group
A − T +	0.06	− 0.01, 0.12		.075		0.16	− 0.46, 0.78		.619
A + T −	− 0.02	− 0.08, 0.04		.520		− 0.31	− 0.87, 0.26		.287
A + T +	− 0.06	− 0.13, 0.01		.104		− 0.34	− 1.06, 0.38		.356
Time	− 0.02	− 0.02, − 0.01		< .001		− 0.01	− 0.10, 0.09		.852
Group × time
A − T + × time	− 0.01	− 0.02, 0.00		.083		− 0.08	− 0.27, 0.11		.388
A + T − × time	− 0.00	− 0.01, 0.00		.349		− 0.19	− 0.36, − 0.02		.029
A + T + × time	− 0.02	− 0.03, − 0.01		< .001		− 0.59	− 0.80, − 0.37		< .001

Abbreviations: CI Confidence interval, ICV Intracranial volume, NA Not applicable, PACC Preclinical Alzheimer Cognitive Composite, SMC Subjective memory concern

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