Table 1 Participant characteristics by amyloid and tau positivity/negativity classification
From: Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals
|  | A + T +  (n = 48) | A + T −  (n = 86) | A − T +  (n = 63) | A − T −  (n = 170) |
|---|---|---|---|---|
Baseline Characteristics | ||||
 Age, mean (SD), y | 76.3 (5.1) | 73.4 (5.9) | 75.8 (6.6) | 72.6 (5.5) |
 No. of male (%) | 21 (44) | 40 (47) | 28 (44) | 85 (50) |
 Education, mean (SD), y | 16.2 (2.5) | 16.4 (2.7) | 16.5 (2.7) | 16.3 (2.6) |
Ethnicity (%) | ||||
 Not Hispanic/Latino | 47 (98) | 84 (98) | 61 (97) | 160 (94) |
 Hispanic/Latino | 1 (2) | 2 (2) | 1 (2) | 8 (5) |
 Unknown | 0 (0) | 0 (0) | 1 (2) | 2 (1) |
Race (%) | ||||
 American Indian/Alaskan native | 0 (0) | 1 (1) | 0 (0) | 0 (0) |
 Asian | 0 (0) | 1 (1) | 1 (2) | 2 (1) |
 Black | 2 (4) | 8 (9) | 1 (2) | 13 (8) |
 White | 46 (96) | 72 (84) | 61 (97) | 154 (91) |
 More than one race | 0 (0) | 4 (5) | 0 (0) | 1 (1) |
Subjective memory concern (%) | 13 (27) | 17 (20) | 17 (27) | 48 (28) |
APOEε4 allele = 1 (%) | 25 (52) | 29 (34) | 13 (21) | 27 (16) |
APOEε4 allele = 2 (%) | 2 (4) | 6 (7) | 0 (0) | 1 (1) |
PACC, mean (SD) |  − 0.97 (2.41) |  − 0.30 (2.80) |  − 0.10 (2.72) | 0.07 (2.33) |
MMSE, mean (SD) | 29.1 (1.2) | 29.1 (1.1) | 28.9 (1.3) | 29.1 (1.1) |
CDR-SB (%) | ||||
 0 | 43 (90) | 76 (88) | 58 (92) | 161 (95) |
 0.5 | 4 (8) | 10 (12) | 5 (8) | 9 (5) |
 1 | 1 (2) | 0 (0) | 0 (0) | 0 (0) |
CSF Aβ42, mean (SD), pg/mL | 706.8 (177.8)a | 689.9 (203.2) | 1548.5 (226.8)b | 1479.3 (230.3)b |
CSF tau, mean (SD), pg/mL | 346.5 (73.9) | 173.1 (49.2)c | 349.2 (69.1) | 197.6 (39.9) |
CSF p-tau181, mean (SD), pg/mL | 35.5 (8.7) | 16.0 (4.7)d | 31.3 (6.8) | 17.3 (3.5) |
Whole brain volume, mean (SD), cm3 | 1061.949 (94.060) | 1059.643 (102.777) | 1045.114 (96.797) | 1073.724 (109.641) |
Ventricular volume, mean (SD), cm3 | 39.782 (19.863) | 47.447 (24.799) | 31.686 (14.950) | 34.223 (14.294) |
Hippocampal volume, mean (SD), cm3 | 7.360 (0.846) | 7.395 (0.943) | 7.291 (0.976) | 7.607 (0.920) |
Cortical thickness, mean (SD), mm | 2.84 (0.25) | 2.92 (0.28) | 2.95 (0.26) | 2.95 (0.21) |
Follow-up characteristics | ||||
 Follow-up, mean (SD), y | 4.4 (3.1) | 4.5 (3.0) | 5.6 (3.7) | 5.5 (3.5) |
 Follow-up CSF measurements available (%) | 32 (67) | 44 (51) | 29 (46) | 107 (63) |
Progression to amyloid-positive (%) | NA | NA | 6 (10) | 14 (8) |
Progression to tau-positive (%) | NA | 7 (8) | NA | 10 (6) |
Progression to dementia (%) | 6 (12) | 5 (6) | 4 (6) | 3 (2) |