Fig. 4

Changes in longitudinal MRI measurements and cognitive performance by amyloid and tau positivity/negativity classification over 7.5 years. a-e Trajectories of modeled mean profiles of whole brain volume, lateral ventricular volume, hippocampal volume, cortical thickness, and PACC scores based on a generalized linear mixed-effects model and 95% confidence bands. The models were controlled for baseline age, APOE ε4 status, sex, number of years of education, and baseline intracranial volume (only for the volumetric measures). Abbreviations: A −  = amyloid negative; A +  = amyloid positive; PACC = Preclinical Alzheimer Cognitive Composite; T −  = tau negative; T +  = tau positive