Fig. 4

Decreases and increases of FC vs. YWD predicted by the biophysical model. AD from HIC (panel A), AD from LAtam (panel B), bvFTD from HIC (panel C) and bvFTD from Latam (panel D). The sagittal anatomical overlays present the top 5% of pairwise FC connections in terms of their negative (green for AD, purple for bvFTD) and positive (grey in both cases) Spearman correlation with YWD. The radar plots indicate a significant overlap of the regions with negative FC changes vs. YWD and DMN/EXEC RSN for AD, and with SN RSN for bvFTD. VN: visual network, SN: salience network, MN: motor network, EXEC: executive control network, DMN: default mode network; FC; functional connectivity, YWD: years with disease; AD: Alzheimer’s disease; bvFTD: behavioral variant frontotemporal dementia