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Table 3 Cognitive profile and MRI CAA-burden score in patients and controls

From: Neuropsychiatric symptoms with focus on apathy and irritability in sporadic and hereditary cerebral amyloid angiopathy

n

sCAA, all

82

sCAA ICH+

23

sCAA ICH-

59

D-CAA, all

56

D-CAA symptomatic

25

D-CAA presymptomatic

37

Controls

43

Executive Function, Z-score* mean(SD)

-0.1 (1.2)

-0.3 (1.6)

-0.1 (1.1)

0.3 (1.2)

0.1 (1.3)

0.6 (1.0)

0.6 (0.7)

Processing speed, Z-score* mean(SD)

-0.8 (1.3)

-1.0 (1.5)

-0.7 (1.2)

-0.3 (1.2)

-0.6 (1.4)

-0.1 (0.9)

0.2 (0.7)

Memory, Z-score* mean(SD)

-0.7 (1.0)

-1.0 (1.1)

-0.6 (1.0)

-0.7 (0.9)

-1.1 (0.9)

-0.4 (0.8)

0.4 (0.8)

CAA-burden score, median[IQR]

4 [4,5]

4 [3,6]

4 [4,5]

4 [1,5]

4 [4,5]

1 [1,4]

1 [1,1]

Frontal lobe cSS, n(%)

47 (57)

12 (52)

35 (59)

14 (29)

10 (40)

4 (16)

0 (0)

Frontal lobe CMB, n(%)

       

 0

11 (13)

3 (16)

8 (16)

20 (25)

1 (4)

19 (76)

39 (91)

 1–10

35 (43)

10 (53)

25 (51)

1 (2)

1 (4)

0 (0)

2 (5)

 11–20

4 (5)

1 (5)

3 (6)

6 (11)

5 (20)

1 (4)

0 (0)

>20

18 (22)

5 (26)

13 (27)

21 (38)

16 (64)

5 (20)

0 (0)

  1. cSS cortical superficial siderosis; CMB cerebral microbleeds; D-CAA Dutch-type cerebral amyloid angiopathy; sCAA sporadic CAA
  2. * age, sex and education adjusted Z-scores