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Table 2 Prevalence of apathy and irritability in patients with CAA and controls

From: Neuropsychiatric symptoms with focus on apathy and irritability in sporadic and hereditary cerebral amyloid angiopathy

n

sCAA, all

82

sCAA ICH +

23

sCAA ICH-

59

D-CAA, all

56

D-CAA symptomatic

25

D-CAA presymptomatic

31

Control

43

NPI-Q

       

 Administered, n(%)

74 (90)

21 (88)

53 (91)

51 (91)

22 (88)

29 (94)

41 (95)

 Total, median[IQR]

1 [0,3]

1 [1,2]

0 [0,3]

1 [0,2]

1 [0,4]

0 [0,2]

0 [0,0]

 Severity, median[IQR]

1 [0,3]

2 [0,3]

1 [0,3]

0 [0,3]

1 [0,5]

0 [0,2]

0 [0,0]

 Caregiver burden if ≥ 1 NPS, median[IQR]

4 [3,6]

4 [2,6]

4 [3,9]

3 [2,8]

4 [2,9]

3 [2,3]

3 [2,4]

Starkstein Apathy Scale

       

 Administered, n(%)

74 (90)

21 (88)

53 (91)

53 (95)

24 (96)

29 (94)

42 (98)

 Score, median[IQR]

12 [7,17]

12 [8,16]

11 [7,18]

12 [7,16]

11 [6,18]

12 [8,15]

6 [3,8]

 Apathy present, score ≥ 14, n(%)*

12 (31)

5 (28)

7 (33)

19 (37)

10 (44)

9 (31)

1 (7)

Irritability Scale

       

 Administered, n(%)

42 (51)

19 (79)

23 (40)

52 (93)

23 (92)

29 (94)

15 (35)

 Score, median[IQR]

9 [3,14]

8 [3,10]

10 [4,16]

8 [2,15]

8 [4,14]

5 [1,14]

6 [3,12]

 Irritability present, score ≥ 14, n(%)*

12 (29)

4 (21)

8 (35)

14 (27)

6 (26)

8 (28)

4 (27)

CES-D

       

 Administered, n(%)

36 (44)

16 (67)

20 (34)

38 (68)

14 (56)

24 (77)

14 (32)

 Depressed, score ≥ 16, n(%)*

17 (47)

8 (50)

9 (45)

18 (47)

6 (43)

12 (50)

1 (7)

  1. CES-D Center for Epidemiological Studies Depression scale; D-CAA Dutch-type cerebral amyloid angiopathy; sCAA sporadic CAA; NPI-Q Neuropsychiatric Inventory Questionnaire, informant based
  2. * Reported as % of administered questionnaire/interview