Fig. 4
From: Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer’s disease
Inflammation-induced cerebral capillary oxygen reduction in WT and AD mice brain. (A) Example survey scan images overlaid with SO2 values in measured capillary segments at z = 200 μm taken on day 0 (before LPS injection), day 7 and day 14 (with continuous LPS injection) inside an AD mouse brain. Scale bar = 100 μm. (B) Histogram showing layer-specific SO2 distributions in all measured capillary points from all animal samples in both cohorts. (C-D) Capillary SO2 and the corresponding coefficient of variation (CV) at baseline (day 0), and with LPS-induced inflammation (day 7 and 14) in WT and AD mice brain in cortical layer I, II/III, and IV. Each bar represents mean ± standard error over all measured mice in each cohort. Connected scatterplot shows the SO2 of each individual mouse. (E) Absolute changes in capillary SO2 in WT and AD mice with 7 and 14 days of LPS injection. ΔSO2 is calculated by subtracting the SO2 on day 0 from the SO2 on day 7 or 14