Fig. 3
From: Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer’s disease
Inflammation-induced arteriole and venule oxygen reductions in WT and AD mice brain. (A) Example survey scan images overlaid with SO2 values in measured penetrating vessels at z = 200 μm taken on day 0 (before LPS injection), day 7 and day 14 (with daily LPS administration) in an AD mouse brain. Scale bar = 100 μm. (B-C) Arteriole and venule SO2 measured on day 0, and day 7 and day 14 in WT and AD mice at cortical layer I, II/III, and IV. Each bar represents mean ± standard error over all measured mice in each cohort. Connected scatterplot shows the SO2 of each individual mouse. (D) Depth-dependent oxygen extraction (DOE) of WT and AD mice on day 0, day 7 and day 14. (E) Systemic oxygen saturation measurements during a neuroinflammatory stimulus, induced by 14-days of daily LPS administration (n = 3 in each cohort). Steady SpO2 values impugn the prospect of LPS-induced impairments to pulmonary blood oxygenation