Fig. 2
From: Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer’s disease
Baseline (pre LPS administration) measurement of cortical intravascular oxygenation and capillary flux in AD and WT mice. A 2D survey scan images of pO2 measurements in diving vessels at 50 μm to 400 μm below the pial surface (z = 0 μm). scale bar = 100 μm. Colored dots are pO2-coded measurement points. B Cortical-layer dependent arteriole and venule pO2 and SO2, and cortical depth-dependent oxygen extraction (DOE) in AD and WT mice. Black asterisk symbol reveals the difference between the two cohorts of animals in cortical layer IV. C An example survey scan image of capillary pO2 measurement at cortical depth z = 200 μm. Colored dots are pO2-coded measurement points. Colorbar is shared by A and C. D capillary oxygen and RBC flux. Upper row: cortical-layer-dependent capillary mean-pO2, SO2, and red blood cell (RBC) flux in AD and WT mice. Lower row: coefficient of variation (CV) of capillary pO2, SO2 and RBC flux of AD and WT mice. Data shown as mean ± standard error