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Table 3 Efficiency of serum SV2A in combination with other biomarkers in the diagnosis of aMCI or AD, and the differential diagnosis of AD from other dementias

From: Synaptic vesicle glycoprotein 2 A in serum is an ideal biomarker for early diagnosis of Alzheimer’s disease

 

Con vs. aMCI

Con vs. AD

aMCI vs. AD

AD vs. VaD

AD vs. PDD

NfL

     

 AUC (95%CI)

0.590 (0.517–0.660)

0.645 (0.584–0.702)

0.564 (0.501–0.626)

0.649 (0.579–0.714)

0.679 (0.608–0.744)

 Cutoff (pg/mL)

> 9.68

> 15.53

> 17.66

≤ 18.20

> 19.15

 SEN (%)

73.63

56.10

47.56

67.44

90.00

 SPE (%)

44.12

68.63

64.84

54.88

43.29

GFAP

     

 AUC (95%CI)

0.777 (0.712–0.834)

0.859 (0.811–0.898)

0.663 (0.602–0.721)

0.663 (0.595–0.727)

0.725 (0.657–0.787)

 Cutoff (pg/mL)

> 7.67

> 12.93

> 20.88

> 19.62

> 11.07

 SEN (%)

84.62

75.61

45.12

79.07

56.67

 SPE (%)

63.73

83.33

83.52

50.61

81.10

p-tau217

     

 AUC (95%CI)

0.832 (0.771–0.882)

0.862 (0.814–0.901)

0.561 (0.497–0.622)

0.631 (0.561–0.697)

0.501 (0.428–0.573)

 Cutoff (pg/mL)

> 3.24

> 3.09

> 6.24

> 2.85

NA

 SEN (%)

62.64

67.68

18.29

60.47

NA

 SPE (%)

89.22

87.25

95.60

70.73

NA

SV2A + NfL

     

 AUC (95%CI)

0.771 (0.705–0.828)

0.883 (0.838–0.919)

0.734 (0.676–0.787)

0.856 (0.801–0.901)

0.868 (0.812–0.912)

 Cutoff (pg/mL)

NA

NA

NA

NA

NA

 SEN (%)

100.0*

89.0*

83.5*

80.5*

83.5*

 SPE (%)

71.6†

98.0†

97.8†

97.7†

96.7†

SV2A + GFAP

     

 AUC (95%CI)

0.865 (0.809–0.910)

0.937 (0.900–0.963)

0.764 (0.707–0.814)

0.836 (0.779–0.884)

0.881 (0.827–0.923)

 Cutoff (pg/mL)

NA

NA

NA

NA

NA

 SEN (%)

98.9*

93.3*

78.7*

86.6*

93.3*

 SPE (%)

81.4†

98.0†

97.8†

93.0†

100.0†

SV2A + p-tau217

     

 AUC (95%CI)

0.891 (0.838–0.931)

0.942 (0.906–0.967)

0.727 (0.667–0.780)

0.819 (0.760–0.869)

0.855 (0.797–0.901)

 Cutoff (pg/mL)

NA

NA

NA

NA

NA

 SEN (%)

98.9*

93.3*

65.2*

93.9*

88.4*

 SPE (%)

95.1†

100.0†

100.0†

93.0†

93.3†

SV2A + GFAP + NfL + p-tau217

     

 AUC (95%CI)

0.918 (0.870–0.952)

0.962 (0.931–0.982)

0.790 (0.735–0.838)

0.864 (0.810–0.908)

0.896 (0.844–0.935)

 Cutoff (pg/mL)

NA

NA

NA

NA

NA

 SEN (%)

100.0*

100.0*

92.1*

98.2*

97.6*

 SPE (%)

98.0†

100.0†

100.0†

100.0†

100.0†

  1. Note: Logistic regression was used to evaluate predictive models and receiver operating characteristic (ROC) curves constructed from the logistic scores. The Youden index was calculated to determine the best cutoff regarding sensitivity and specificity for the single indicator. The *parallel test and †serial test was used to calculate the sensitivity and specificity of the combined diagnostic models, respectively. Abbreviations: 95% CI, 95% confidence interval; AD, Alzheimer’s disease; aMCI, amnestic mild cognitive impairment; AUC, area under the curve; GFAP, glial fibrillary acidic protein; NfL, neurofilament light; NA, not available; PDD, Parkinson’s disease dementia; p-tau217, phosphorylated tau; SEN, sensitivity; SPE, specificity; SV2A, synaptic vesicle glycoprotein 2 A; VaD, vascular dementia; vs., versus
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Alzheimer's Research & Therapy

ISSN: 1758-9193