Fig. 4
From: Glymphatic inhibition exacerbates tau propagation in an Alzheimer’s disease model
Chronic glymphatic inhibition appears to exacerbate volumetric changes caused by tau propagation, in extra-hippocampal/cortical regions. Volcano plot of comparisons between groupwise regional interhemispheric volume ratios and hemispheric equality, indicating both an upper-left (accentuated ispi < contralateral difference) and upper-right (accentuated ispi > contralateral difference) shift away from the origin (bottom centre) of the plot in P301S P301SBE TGN-020 treated group datapoints compared to vehicle treated controls. For anatomical reference, horizontal slice images are shown (left, -4 from Bregma; right, 2 mm from Bregma) with regions colour scaled based on their significant interhemispheric differences (ipsi < contralateral in blue (left), ipsi > contralateral in red (right)) in each of the treatment groups. n = 8 per group (4♂:4♀)