Human in vivo evidence of associations between herpes simplex virus and cerebral amyloid-beta load in normal aging

Table 3 Effects of the interaction anti-HSV-1 IgG levels × Aβ load on rs-FC patterns

FC seed Peak location of significant result	Extent of change (mm²)	MNI	R²	F_8,58	\({rho}_{local}\)	CI_95%	BF₁₀
R anterior cingulate (FC seed)
L superior temporal (p_cluster= 0.005)	289	-48 14 − 13	0.20	15.6	0.95^L	-1.49 – -0.57	128^E
R precuneus (p_cluster= 0.02)	499	8–41 45	0.22	18.0	0.92^L	0.56–1.40	9^M
*R inferior temporal gyrus (FC seed)*
R superior temporal (p_cluster= 0.01)	425	56 − 41 3	0.16	12.1	0.84^L	-1.31 – -0.56	7^M

MNI coordinates are in MNI152 space. Local effect size (rho_local): ^L large. CI_95%: 95% confidence interval. BF₁₀: Bayes factor derived from Bayesian linear regression analyses. The superscript of the BF₁₀ indicates the qualitative interpretation of the magnitude of evidence in favor of the alternative hypothesis as opposed to the null hypothesis: ^M moderate; ^E extreme. L: left; R: right

ISSN: 1758-9193