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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Human in vivo evidence of associations between herpes simplex virus and cerebral amyloid-beta load in normal aging

Fig. 3

Moderating role of anti-HSV IgG levels in the relationship between regional FBB binding and rs-FC patterns. Positive and negative partial correlations adjusted by age, sex and APOE4 are displayed in warm and cool colors, respectively. (A) Abnormal pattern of rs-FC using the right anterior cingulate as FC seed (upper panel). Only participants showing the highest anti-HSV IgG levels (pink) exhibited significant positive associations between Aβ load in the right anterior cingulate and rs-FC of the right anterior cingulate with the right precuneus (bottom panel). (B) Abnormal pattern of rs-FC using the right anterior cingulate as FC seed (upper panel). Only participants showing the highest anti-HSV IgG levels (pink) exhibited significant negative associations between Aβ load in the right anterior cingulate and rs-FC of the right anterior cingulate with the left superior temporal cortex (bottom panel). (C) Abnormal pattern of rs-FC using the right inferior temporal as FC seed (upper panel). Only participants showing the highest anti-HSV IgG levels (pink) exhibited significant negative associations between Aβ load in the right inferior temporal cortex and rs-FC of the right inferior temporal cortex with the right superior temporal sulcus (bottom panel). This pattern of rs-FC appeared significantly opposite in older adults showing the lowest anti-HSV IgG levels (green). Right: right, L: left

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Alzheimer's Research & Therapy

ISSN: 1758-9193