Table 2 Association between NPI total scores with AD biomarkers and CSVD markers in in whole sample

Age

0.042 (-0.047, 0.131)

0.356

-

-

-

-

Sex

2.462 (1.095, 3.830)

<0.001

-

-

-

-

Education

-0.343 (-0.602, -0.084)

0.010

-

-

-

-

APOE ε4 carrier status

-0.105 (-1.489, 1.279)

0.881

-

-

-

-

Clinical diagnosis

3.239 (1.753, 4.725)

<0.001

-

-

Aβ₄₂ (pg/ml)

-0.013 (-0.027, 0.001)

0.067

-0.007 (-0.023, 0.008)

0.355

-

-

p-tau₁₈₁ (pg/ml)

0.011 (-0.013, -0.035)

0.388

0.005 (-0.020, 0.030)

0.690

-

-

t-tau (pg/ml)

0.006 (-0.005, 0.018)

0.288

0.003 (-0.010, 0.016)

0.625

-

-

p-tau₁₈₁/Aβ₄₂

1.885 (-0.878, 4.648)

0.181

1.103 (-1.862, 4.068)

0.465

-

-

t-tau/Aβ₄₂

0.655 (-0.647, 1.958)

0.323

0.295 (-1.141, 1.731)

0.687

-

-

PVL-WMH score

0.147 (-0.677, 0.971)

0.726

-0.023 (-0.951, 0.906)

0.962

-

-

DWM-WMH score

0.182 (-0.617, 0.981)

0.655

0.041 (-0.834, 0.915)

0.927

-

-

BG-PVS score

-0.106 (-1.619, 1.407)

0.891

-0.116 ( -1.586, 1.355)

0.986

-

-

CSO-PVS score

-0.136 (-0.490, 0.218)

0.144

-0.449 (-1.334, 0.436)

0.458

-

-

Microbleeds

2.977 (1.189, 4.765)

0.001

2.350 (0.681, 4.019)

0.006

2.424 (0.749, 4.099)

0.005

Lacune

1.793 (0.051, 3.535)

0.044

1.373 (-0.365, 3.112)

0.121

-

-